The orphan nuclear receptor 4A1 (NR4A1) is overexpressed in pancreatic cancer and exhibits pro-oncogenic activity, and NR4A1 silencing and treatment with its inactivators has been shown to inhibit pancreatic cancer cells and tumor growth.In this study, we identified broussochalcone A (BCA) as a new NR4A1 inhibitor and demonstrated that BCA alesis v

Mesencephalic dopaminergic neurons were suggested to be a critical physiopathology substrate for addiction disorders.Among neuroadaptive processes to addictive drugs, structural plasticity has attracted attention.While structural plasticity occurs at both pre- and post-synaptic levels in the mesolimbic dopaminergic system, the present review focuse

The purpose of this study was to determine the relationship between organizational cynicism and organizational anti-citizenship behavior with the Mediating Role of organizational envy.The following survey was done with descriptive and structural equation modeling type.By Stratified randomized sampling 191 teachers of Zahedan were studied with throu

Computers are an integral part of modern radiology practice.They are used in different radiology modalities to acquire, process, and postprocess imaging data.They have had a dramatic influence on contemporary radiology practice.Their impact has extended further with the emergence of Digital Imaging and Communications in Medicine (DICOM), Picture Ar

With increasing distribution of endovascular stroke therapies, transient middle cerebral artery occlusion (tMCAO) in mice now more than ever depicts a relevant patient population with recanalized M1 occlusion.In this case, the desired therapeutic effect of blood flow restauration is accompanied by breakdown of the blood-brain barrier (BBB) and seco